What is IGNITE-TX
The IGNITE-TX Study, a trial aimed at advancing genetic testing for Hereditary Breast and Ovarian Cancer (HBOC) syndrome and Lynch syndrome (LS), holds promise in addressing a significant concern highlighted by the National Comprehensive Cancer Network (NCCN). The NCCN advises that all at-risk relatives of individuals with these syndromes should undergo genetic counseling and consider cascade genetic testing. However, the current uptake of cascade genetic testing among relatives stands at fewer than 50%, indicating an opportunity to improve these rates within the patient population through this study.
Being aware of our genetic risks empowers us to make informed decisions
Why?
Understanding our genetic risks not only helps us make informed healthcare decisions for ourselves but also benefits our relatives. Participants in this study will provide basic information to determine eligibility. Any uncertainties regarding genetic test results or inquiries about the study will be addressed by our dedicated support team, available at every step.
Our objectives
The primary objectives of the IGNITE-TX Study include aiding families in understanding their cancer risk linked to HBOC and LS, sharing genetic testing results, and facilitating access to essential information and resources for those considering genetic testing. It’s crucial to note that both syndromes increase the likelihood of cancer occurrence in both men and women. This trial presents a unique opportunity to enhance genetic testing.
Our Team
J. Alejandro Rauh-Hain, MD, MPH
Gynecologic Oncologist
Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center
Núria Agustí, MD
Research Coordinator
Study Manager
Postdoctoral fellow
Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center
Karla L. Barajas, MD
Research Coordinator
Postdoctoral fellow
Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center
Alexa Kanbergs, MD-ScM, MS
Gynecologic Oncology Fellow
Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center
Maria Iniesta, MD, MPH
Assistant Professor
Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center
Roni N. Wilke, MD, MPH
Assistant Professor
Department of Gynecologic Oncology and Reproductive Medicine, MD Anderson Cancer Center
Erica Bednar, MS, MPH, CGC
Senior Healthcare Systems Improvement Specialist, Certified Genetic Counselor
Cancer Prevention and Control Platform, University of Texas MD Anderson Cancer Center
Tara B. Coffin, PhD, MEd, CIP, CLE
Regulatory Specialist, Research & Communications Consultant
MD Anderson Cancer Center
Beth Y. Karlan, MD
Nancy Marks Endowed Chair in Women’s Health Research, Professor and Vice Chair, Department of Obstetrics and Gynecology, Director, Cancer Population Genetics
UCLA Jonsson Comprehensive Cancer Center
Sayoni Lahiri, MS, CGC
Certified Genetic Counselor
Simmons Comprehensive Cancer Center, UT Southwestern Medical Center
Sara Pirzadeh-Miller, MS, CGC
President-Elect, National Society of Genetic Counselors; Director, Cancer Genetics Program
UT Southwestern Simmons Comprehensive Cancer Center
Kathy Pratt, BSN, RN, OCN, CBCN, ONN-CG
Genetic Nurse Navigator
UT Southwestern Medical Center, Dallas, TX
Contact Us
If you have questions about the study or want more information, you can contact the study team via phone 713-792-9155 or email ignitestudy@mdanderson.org
